Endothelial Defense™ with Full-Spectrum Pomegranate™ and CORDIART™, 60 softgels

Boost Endothelial Function For Vascular Health

Optimal heart health depends on many factors, including proper endothelial function.1 Even with cholesterol/glucose levels in the healthy range, aging individuals need to maintain youthful integrity of their endothelium—the thin layer of cells lining the interior of the entire circulatory system.

Based on published studies showing improvements in endothelial function, health-conscious people have been drinking pomegranate juice or taking a standardized pomegranate supplement.

Going Beyond Pomegranate

The addition of CORDIART™ (extract from sweet orange peels) to pomegranate provides another vascular benefit by activating endothelial production of nitric oxide, which signals the smooth muscles to relax, inducing vasodilation to support healthy circulation.

In clinical research, 500 mg of CORDIART™ alone produced an 18% improvement in flow mediated dilation, a direct marker of endothelial function. CORDIART™ also inhibited the pro-inflammatory factors C-reactive protein and serum amyloid A that interrupt healthy nitric oxide production.2

Triple-Action Protection

For those seeking the convenience of three nutrients clinically shown to help with blood flow and age-related changes in endothelial function,2-6 the newly formulated Endothelial Defense™ provides GliSODin®, Full-Spectrum Pomegranate™, and CORDIART™.

The orally active form of superoxide dismutase (SOD)—called GliSODin®—has been clinically demonstrated to support healthy arterial function and structure, while boosting levels of the body’s protective enzymes—SOD and catalase.4-6 The new Endothelial Defense contains a potent dose of GliSODin® along with 500 mg
of CORDIART™.

The new Endothelial Defense™ also provides standardized pomegranate juice extract and a proprietary pomegranate flower and seed oil blend. These extracts from different parts of the pomegranate plant provide potent polyphenols clinically shown to support healthy blood flow, youthful lipid and glucose metabolism, and healthy inflammatory factors.2,3,7-9

Endothelial Defense™ with Full-Spectrum Pomegranate™ and CORDIART™ addresses many factors that promote youthful endothelial function in a dose of two softgel capsules daily.

References
1. Annu Rev Physiol. 2006;68:51-66.
2. Bioactor B.V.;2013.
3. Altern Med Rev. 2008 Jun;13(2):128.
4. Eur Ann Allergy Clin Immunol. 2007 Feb;39(2):45-50.
5. Phytother Res. 2004 Dec;18(12):957-62.
6. Free Radic Res. 2004 Sep;38(9):927-32.
7. Adv Biomed Res. 2014; 3:100.
8. J Nutr Sci. 2012; 1:e9.
9. Biofactors. 2015 Jan-Feb;41(1):44-51.

USAGE

SUPPLEMENT FACTS

WHAT IS THE ENDOTHEILIUM?

The endothelium is the single layer of cells that lines the inside walls of blood vessels. The endothelium cells are essentially a barrier between the flowing blood and the lining of the blood vessels throughout the entire body.

WHAT IS ITS FUNCTION?

Endothelial cells are involved in many aspects of keeping the heart, blood flow, and overall cardiovascular system healthy. Because blood flow is important for every organ and system throughout the body, the mechanisms that the endothelium perform are crucial for overall health. When they do not function properly, there is an increased risk for developing many harmful conditions. Some of the main and most important functions of the endothelium are:

• Acting as a blood barrier - the endothelium controls the passing of materials and white blood cells into and out of the bloodstream.
• Helping to keep down inflammation- when permeability of the blood vessels occur, inflammation takes place throughout the body which can lead to the development of many chronic disease. The endothelial layer helps to keep vessels from becoming too permeable
• Helping to make sure blood can clot at a healthy level
• Assisting in the formation of new blood vessels
• Helping to control the level of blood pressure by reducing hypertension
• Aiding in repairmen of damaged organs by bringing proper blood flow to the

PROTECTING THE ENDOTHEILIUM

When the endothelial does not function properly, vascular diseases (those that effect the heart) often take place; this is why it is paramount to maintain their health.  Impaired endothelial function can lead to problems with cholesterol, blood pressure, and increase risk for serious coronary artery diseases, as well as conditions due to increased inflammation in the body such as diabetes and arthritis. The jobs of the endothelium are essential to many important parts of the body, therefore making sure that they operate correctly is extremely important.