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Mitochondrial Energy Optimizer with BioPQQ™, 120 capsules

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120 capsules
Vegetable Capsule
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120 capsules
Vegetable Capsule

Mitochondrial Energy Optimizer with BioPQQ™
120 capsules

Back in year 2001, we at Life Extension™ faced a dilemma. Potent nutrients had been discovered to counteract undesirable age-related changes. Yet the cost of the individual ingredients was too high. So we combined these nutrients into one formula so consumers could obtain them at an affordable price.

Over the years, the published data about the amino acid taurine has grown enormously. In addition to protecting cardiac function, taurine has demonstrated powerful brain-boosting effects that include enhancing neurites1 and promoting new brain cell formation.2

These new findings indicate that taurine is more important to supplement with than acetyl-l-carnitine arginate. In addition, taurine costs much less than acetyl-l-carnitine arginate.

So we’ve re-formulated the popular Mitochondrial Energy Optimizer using taurine and reduced the retail price over 20%.

Aging is characterized by inflammation, glycation, mitochondrial decay, and loss of cellular structure/function. Mitochondrial Energy Optimizer provides the following nutrients to help neutralize these changes:

  • CARNOSINE: As humans age, proteins in their bodies become irreversibly damaged by glycation reactions. Glycation can lead to alterations of normal cell function. Carnosine is a powerful anti-glycating agent, and protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.3-7
  • PQQ: This micronutrient has been shown to trigger the growth of new mitochondria in aging cells!8 PQQ also activates genes involved in protecting the delicate structures within the mitochondria.9-12
  • LUTEOLIN: Systemic inflammation is involved in most consequences of aging. Culprits behind inflammatory reactions are pro-inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha. Luteolin is a flavonoid that has been shown to help suppress these inflammatory cytokines.13-17
  • BENFOTIAMINE: Benfotiamine blocks multiple destructive biochemical pathways, including AGEs’ formation pathway,18-22 which is induced by higher than desirable blood glucose levels.23 Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels. In addition, benfotiamine exhibits direct antioxidative capacity and supports DNA function.24
  • PYRIDOXAL 5’-PHOSPHATE: Aging results in the formation of advanced glycation end products throughout the body. Pyridoxal 5’-phosphate is the active form of vitamin B6 that has been shown to protect against both lipid and protein glycation reactions.25-28
  • R-LIPOIC ACID: Destructive free radical activity in the mitochondria plays a major role in the loss of cellular vitality. A microencapsulated Bio-Enhanced® R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals.29-33
  • TAURINE: This free amino acid supports whole-body health and boosts new brain cell formation in the area of the brain connected to learning and memory.1

1. Stem Cell Res. 2015 May;14(3):369-79.
2. Neurosci Lett. 2015 Mar 17;590:52-7.
3. Hormones (Athens). 2008 Apr-Jun;7(2):123-32.
4. Protein Pept Lett. 2008;15(4):385-91.
5. J Alzheimers Dis. 2007 May;11(2):229-40.
6. Ann N Y Acad Sci. 2006 May;1067:369-74.
7. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
8. J Biol Chem. 2010 Jan1;285:142-52
9. Alt Med Rev. 2009; 14(3):268-77.
10. Entrez Gene: PARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [Homo sapiens] GeneID: 10891.
11. Entrez Gene: CREBBP CREB binding protein [Homo sapiens] GeneID: 1387.
12. PLoS One. 2011;6(7):e21779.
13. Life Sci. 2007 Nov 30;81(23-24):1602-14.
14. J Nutr. 2006 Jun;136(6):1517-21.
15. Biochem Pharmacol. 2005 Jan 15;69(2):241-8.
16. Immunology. 2005 Jul;115(3):375-87.
17. Am J Respir Crit Care Med. 2002 Mar 15; 165(6):818-23.
18. Eur J Pharmacol. 2006 Jul 10;541(1-2):95-105.
19. Nat Med. 2003 Mar;9(3):294-9.
20. Diabetes. 2006 Aug;55(8):2231-7.
21. Pharmacol Res. 2010 Jun;61(6):482-8.
22. Diabetes Care. 2006 Sep;29(9):2064-71.
23. Circ Heart Fail. 2010 Mar;3(2):294-305.
24. Acta Diabetol. 2001;38(3):135-8.
25. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7.
26. J Lipid Res. 2006 May;47(5):964-74.
27. Biochem Biophys Acta. 2001 Feb.14;1535(2):110-9.
28. J Am Soc Nephrol. 2005 Jan; 16(1):144-50.
29. Life Sci.1988;43(21):1725-31.
30. Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9.
31. FASEB J. 1999 Feb;13(2):411-8.
32. Antioxid Redox Signal. 2000 Fall;2(3):473-83.
33. Biochem Mol Biol Int. 1995 Oct;37(2):361-70.
34. Amino Acids. 2015 Apr;47(4):735-44.



  • Take two (2) capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.
  • This product can be taken with or without food.



Serving Size 4 capsules

Servings Per Container 30

Amount Per Serving

Vitamin B6 (as pyridoxal 5’-phosphate)

100 mg


18 mg


1000 mg


800 mg


150 mg

R-Lipoic Acid (as microencapsulated Bio-Enhanced® stabilized Na-RALA sodium R-lipoate)

150 mg

BioPQQ® Pyrroloquinoline quinone disodium salt

10 mg

Luteolin [from orange extract (fruit)]

8 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, candelilla wax, beeswax, stearic acid, silica, corn starch, acacia gum, calcium silicate.


Non-GMO, BioPQQ® is a registered trademark of MGC (Japan). Bio-Enhanced® is a registered trademark of Geronova Research, Inc.


Product Reviews

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  1. Review

    Posted by richard (www.lef.org reviewer) on 6th Feb 2014

    Since I do not have a laboratory I can only assume that the product is of value. Since this product advertises Mitochondrial Energy Optimizer , you will have to tell me how to track this in order for me to write a review.

  2. A life saver!

    Posted by selwyn mungo (www.lef.org reviewer) on 3rd Feb 2014

    After using coconut oil to correct obvious major memory and general life skill issues a gap still remained between where I was mentally and where I used to be. After ten minutes of taking two caps of this product my mind snapped back to where I never, ever thought I'd get back to again. Miraculous. Not a day goes by when I don't mentally get on my knees and thank those responsible for this formulation. Thank you. Thank you.

  3. I take this product on an empty stomach.

    Posted by Maria Byrne (www.lef.org reviewer) on 31st Jan 2014

    I take it before my breakfast on an empty stomach. I find that since I started to take it my hypoglycemia has improved considerably. I can go for a longer period of time without having to have a snack whereas before I started to take it I would have to eat again right after my breakfast.

    My only complaint is the price. It is very expensive.

  4. Premere Anti-aging

    Posted by ProfessorMitch (www.lef.org reviewer) on 30th Jan 2014

    Life depends on energy. Cells produce energy in the Mitochondria. Without energy cells die and people die. You cannot get energy from fat without healthy functioning Mitochondria. All cellular processes require energy. I could go on, get the picture. You need this stuff.

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